IL-8→Interleukin-4→Transcription Factors→JunD

• 18415826(IL-8): Effect of budesonide and formoterol on IL-6 and IL-8 release from primary bronchial epithelial cells.

  Formoterol increased the IL-6 release but did not influence the IL-8 release.

• 9316507(Interleukin-4): Mutual inhibition by TGF-beta and IL-4 in cultured human bronchial epithelial cells.

  Consistent with this , IL-4 and TGF-beta effects on IL-8 and fibronectin release were paralleled by changes in mRNA levels.

• 2725496(Transcription Factors): Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.

  This mRNA response was followed by a large increase in the biosynthesis of the c-jun protein (AP-1) , as shown by metabolic labeling and immunoprecipitation analysis.

• 8336952(JunD): In vitro transforming capacities of mouse c-jun:junD chimeric genes.

  We attempted to map the regions of c-jun which are important for transformation by constructing hybrids between c-jun and junD.