IL-8→Hypoxia-Inducible Factor 1→BRCA1

• 18478184(IL-8): Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages.

  Sal thus has a protective effect against t-BHP-induced inflammation and that this , in part , is due to the inhibition of the production of RANTES , MCP-1 , IL-8 and HIF-1alpha via the modulation of the NF-kappaB and mitogen-activated protein kinase (MAPK) pathways.

• 10582706(Hypoxia-Inducible Factor 1): Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

  HIF-1alpha overexpression was detected in only 29 % of primary breast cancers but in 69 % of breast cancer metastases.

• 18030615(BRCA1): High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.

  HIF-1alpha overexpression was significantly more frequent in BRCA1 related breast cancers (27/30 , 90 %) than in sporadic controls (88/200 , 44 %) (P (0.0001).