IL-8→Dexamethasone→Fas Ligand Protein→Receptors, Estrogen→BRCA1

• 18535161(IL-8): Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury.

  Thus , the down-regulation of endogenous H2S production might be involved in the pathogenesis of OA-induced ALI in rats.

• 11778176(Dexamethasone): [Effects of dexamethasone on apoptosis and expression of Fas/FasL system in lung tissues of ALI rats]

  The expression of Fas , FasL mRNA and protein was up-regulated in lung tissues of rats with ALI.

• 10640988(Fas Ligand Protein): Fas ligand is expressed in normal breast epithelial cells and is frequently up-regulated in breast cancer.

  The expression of Fas protein was more heterogeneous in benign and malignant breast tissue , with expression levels ranging from weak to strong , but breast cancer cells frequently exhibited a weaker Fas expression than surrounding residual normal breast epithelial cells.

• 9538123(Receptors, Estrogen): Comparison of variant expression of estrogen receptor mRNA in normal breast tissue and breast cancer.

  Using the RT-PCR , paired cancer and normal breast tissue specimens from 15 patients were analyzed.

• 20346095(BRCA1): Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

  There is a strong association between BRCA1 mutation carrier status and estrogen receptor-negative breast cancer.