IL-1 beta→Intercellular Adhesion Molecule-1→Intercellular Adhesion Molecule-1→STAT2

• 18780953(IL-1+beta): The effects of cured dentin bonding agents on secretion of pro-inflammatory cytokines, IL-1beta and TNF-alpha, by human monocytes.

  Present study evaluated the effects of polymerized DBA on secretion of pro-inflammatory cytokines by normal human monocytes.

• 1347304(Intercellular Adhesion Molecule-1): Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines.

  All other cytokines had no significant effect.

• 19935876(Intercellular Adhesion Molecule-1): Functional cooperation between Stat-1 and ets-1 to optimize icam-1 gene transcription.

  In the present study , we have determined whether the EBSs are also involved in the regulation of ICAM-1 gene transcription by pro-inflammatory cytokines.

• 12972432(STAT2): Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.

  IFNgamma stimulated transcription of a STAT1-dependent reporter gene was impaired by RasV12 , demonstrating a transmodulation of IFN/STAT signaling by activated Ras.