IL-8→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→STAT2

• 18799095(IL-8): Cytokine (IL-6) and chemokine (IL-8) gene polymorphisms among rheumatoid arthritis patients in Taiwan.

  The aim of this study was to examine whether -572 G/C polymorphism in the IL-6 gene and 2767 A/G polymorphism in the 3 ' - untranslated region (UTR) of the IL-8 gene are associated with rheumatoid arthritis (RA).

• 7668906(Tumor Necrosis Factor-alpha): A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.

  OBJECTIVE : To determine whether a polymorphism within the tumor necrosis factor alpha (TNF alpha) gene is associated with susceptibility to , or severity of , rheumatoid arthritis (RA).

• 8615393(Tumor Necrosis Factor-alpha): Protective Role of TNF-alpha in respiratory syncytial virus infection in vitro and in vivo.

  Because the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) may be important in host response to viral infection , HEp-2 cells were treated with TNF-alpha and mice were given TNF-alpha antibody before RSV infection.

• 15994826(STAT2): Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness.

  RSV infection decreased human but not mouse Stat2 levels , so this mechanism of IFN antagonism may contribute to viral host range , as well as immune subversion.