IL-8→Tumor Necrosis Factor-alpha→NF-kappa B→NF-kappa B→c-fos

• 18837094(IL-8): Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: a pilot study in population of Suzhou, China.

  No difference was found in the distribution of genotype of IL-8-251A / T between the healthy control group and AP group neither in the frequency of A and T allele.

• 18580445(Tumor Necrosis Factor-alpha): Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis.

  RESULTS : Major allele frequency in TNF gene was 0.87 for patients with AP and 0.86 for controls.

• 12436048(NF-kappa B): Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?

  Here we investigated whether acute alcohol treatment of human monocytes also inhibits NF-kappaB when induced through activation of the interleukin (IL) -1 or tumor necrosis factor (TNF) receptors.

• 12606947(NF-kappa B): Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.

  We investigated the effects of adenosine on NF-kappaB activation induced by various inflammatory agents in human myeloid KBM-5 cells.

• 19285436(c-fos): Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.

  Here , we demonstrated that the transcription factor c-Fos was responsible for the cAMP-mediated suppression of inflammatory cytokine production.