IL-1 beta→Estrogens→Intercellular Adhesion Molecule-1→Interleukin-10→STAT1

• 18841529(IL-1+beta): Profile of serum IL-1beta and IL-10 shortly after ovariectomy and estradiol replacement in rats.

  Shortly after ovariectomy (at 3 d) serum interleukin-1beta levels significantly increased in ovariectomized rats , treated or not with estradiol , while serum interleukin-10 levels increased only 9 d after ovariectomy.

• 10613736(Estrogens): Estrogen is involved in early alcohol-induced liver injury in a rat enteral feeding model.

  Livers from ovariectomized rats with or without estrogen replacement after 4 weeks of continuous ethanol exposure were compared with nonovariectomized rats in the presence or absence of ethanol.

• 7556590(Intercellular Adhesion Molecule-1): Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNF alpha messenger RNA.

  Upregulation of ICAM-1 in rats fed ethanol may contribute to the inflammatory changes seen in this model.

• 9192770(Interleukin-10): Interleukin-10 inhibits interferon-gamma-induced intercellular adhesion molecule-1 gene transcription in human monocytes.

  Thus , IL-10 inhibits IFN-gamma-induced ICAM-1 expression in monocytes primarily at the level of gene transcription.

• 19940027(STAT1): Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-{gamma}.

  We also demonstrated that the effects of IFN-gamma on SLC26A6 gene expression were mediated via IRF-1 transcription factor.