IL-8→Interleukin 1 Receptor Antagonist Protein→Interleukin-1→Interleukin-1→ATF2

• 19026125(IL-8): IL-6 receptor, IL-8 receptor and TNF-alpha238 (G/A) polymorphisms are not associated with Behcet's disease in patients of German or Turkish origin.

  CONCLUSION : The single nucleotide polymorphisms of the IL-6 and IL-8 receptor genes and the TNF-alpha gene analyzed here do not appear to be associated with Behcet 's disease.

• 18926055(Interleukin 1 Receptor Antagonist Protein): Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma.

  This study was performed to investigate the relationship between polymorphisms of IL-1beta promoter region -511 C/T and IL-1 receptor antagonist (IL-1Ra) gene (IL-RN) and bronchial asthma in Turkish children.

• 15141093(Interleukin-1): Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

  IL-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1beta and protects cultured human islets from glucotoxicity.

• 11181061(Interleukin-1): Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase.

  Expression of inducible nitric oxide synthase (iNOS) and subsequent NO formation induced by IL-1 beta or (IL-1 beta + IFN-gamma) may impair islet function in rodent islets.

• 11399523(ATF2): Glucose potentiates interleukin-1 beta (IL-1 beta)-induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans.

  IL-1 beta causes expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO).