IL-8→Interleukin-1beta→Tumor Necrosis Factor-alpha→c-jun

• 19121063(IL-8): Cytokines in gingival crevicular fluid of adolescents and young adults.

  BACKGROUND/AIM : The purpose of this study was to compare the levels of the cytokines interleukin-1beta (IL-1beta) , IL-4 , and IL-8 in the gingival crevicular fluid (GCF) of adolescents and young adults.

• 16953820(Interleukin-1beta): Analysis of interleukin-1beta-modulated mRNA gene transcription in human gingival keratinocytes by epithelia-specific cDNA microarrays.

  BACKGROUND/OBJECTIVES : Proinflammatory cytokines such as interleukin-1beta are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-kappaB (NF-kappaB).

• 12176740(Tumor Necrosis Factor-alpha): Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages.

  Because TNF-alpha gene expression is under the control of nuclear factor-kappaB (NF-kappaB) , we investigated whether FasL can induce NF-kappaB activation and whether such activation plays a role in FasL-mediated cell death in macrophages.

• 19944115(c-jun): Notexin upregulates Fas and FasL protein expression of human neuroblastoma SK-N-SH cells through p38 MAPK/ATF-2 and JNK/c-Jun pathways.

  Notexin-induced upregulation of Fas and FasL was suppressed by SB202190 (p38 MAPK inhibitor) and S600125 (JNK inhibitor).