IL-1 beta→Helicobacter pylori→Tumor Suppressor Protein p14ARF→ATF3

• 19145908(IL-1+beta): [Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori]

  The presence of proinflammatory allele positively influences eradication therapy , which can be used for determining the risk groups and individualized eradication therapy.

• 16641130(Helicobacter pylori): Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo.

  CONCLUSIONS : LCM of archival specimens has enabled the identification of gastric epithelial genes whose expression is considerably altered after H pylori eradication.

• 12870784(Tumor Suppressor Protein p14ARF): p53 and p14 increase sensitivity of gastric cells to H. pylori-induced apoptosis.

  The p53 tumor suppressor gene is frequently mutated in many cancers , including gastric cancer.

• 15933712(ATF3): Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.

  We report herein that its interaction with p53 , enhanced by genotoxic stress , stabilizes the tumor suppressor thereby augmenting functions of the latter.