IL-8→Transcription Factors→Epidermal Growth Factor→Transcription Factor AP-1→JunD

• 19162161(IL-8): Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells.

  Exposure to high levels of ozone (O (3)) damages respiratory tract epithelial cells.

• 9124608(Transcription Factors): Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells.

  IL-8 mRNA and IL-8 protein levels were also increased after ozone exposure.

• 14713916(Epidermal Growth Factor): Induction of the epidermal growth factor receptor and its ligands in nasal epithelium by ozone.

  In vitro exposure of primary nasal epithelial cell cultures to ozone had no effect on EGFR expression , even though IL-8 release was enhanced.

• 10803405(Transcription Factor AP-1): Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression.

  Examination of EGFR expression of MCF-7 stable cell lines that overexpress c-Jun revealed an increase in EGFR expression.

• 1429597(JunD): Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun.

  In this report we show that CREM antagonists are able to block the transcriptional activation elicited by c-Jun.