IL-1 beta→Interleukin-1beta→Epidermal Growth Factor→c-jun

• 19274529(IL-1+beta): Interleukin-1beta gene (IL-1beta) polymorphisms (SNP -511 and SNP +3953) in thyroid-associated ophthalmopathy (TAO) among the Polish population.

  MATERIALS AND METHODS : The IL-1beta gene polymorphisms at -511 and +3953 regions in 117 TAO patients of Polish origin (ATA/NOSPECS class III or greater) and in 106 controls were studied.

• 18225559(Interleukin-1beta): The interleukin-1 beta gene polymorphism +3953 C/T is not associated with risk for oral cancer.

  BACKGROUND : Elevated serum levels of interleukin-1 beta (IL-1beta) have been previously observed in patients with oral cancer.

• 19388850(Epidermal Growth Factor): Epidermal growth factor genetic variation, breast cancer risk, and waiting time to onset of disease.

  Further , we showed that the waiting time for onset of breast cancer in G homozygous patients for EGF genotypes (55 years) was significantly lower in comparison to A-allele carriers (59 years) (log-rank test : p = 0.038).

• 20121928(c-jun): c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.

  Epidermal growth factor (EGF) - induced cyclooxygenase-2 (COX-2) expression in squamous cell carcinomas is mediated through the extracellular signal-regulated kinase 1/2 and p38 pathways.