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19317746(IL-1+beta): Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura.
These findings suggest that a single nucleotide polymorphism within the IL-1beta (-511) may affect susceptibility to early-onset ITP associated with H. pylori infection.
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11377390(Interleukin-8): Mechanism for Helicobacter pylori stimulation of interleukin-8 production in a gastric epithelial cell line (MKN 28): roles of mitogen-activated protein kinase and interleukin-1beta.
The additive effect of H. pylori and IL-1beta on IL-8 production was inhibited by treatment with a p38 MAPK inhibitor.
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12145100(Cyclooxygenase 2): TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways.
4 : Finally , TNF-alpha , unlike IL-1beta , was unable to promote p38 MAPK phosphorylation , indicating that the failure of TNF-alpha to induce PGHS-2 expression is linked , at least in part , to its inability to activate p38 MAPK signalling pathway.
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9605977(Interleukin-1): Interleukin-1beta expression after inhibition of protein phosphatases in endotoxin-tolerant cells.
Endotoxin-tolerant cells have decreased transcription activation potential , while IL-1beta mRNA stability remains responsive to protein phosphorylation.
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20478717(NF-KB): Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue.
Endotoxin provokes cardiac dysfunction , and induction of tolerance to endotoxin has therapeutic potential.