IL-1 beta→Interleukin-6→NF-kappa B→Interleukin-6→ATF2

• 19555923(IL-1+beta): Salivary levels of IL-1beta, IL-6, IL-8, and TNF-alpha in patients with burning mouth syndrome.

  RESULTS : No significant differences were found in the salivary levels of IL-1beta , IL-6 , IL-8 , and TNF-alpha in BMS patients compared with controls.

• 12873450(Interleukin-6): Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line.

  The data suggest that wogonin may inhibit IL-6 and IL-8 mRNA expression via the suppression of NF-kappaB binding activities.

• 16435581(NF-kappa B): p38 MAPK and NF-kappaB on IL-6 release in human gingival fibroblasts.

  Both the NF-kappaB inhibitors in the presence of SB203580 had more inhibitory effect on IL-6 release.

• 18942706(Interleukin-6): Nuclear factor kappa B subunit p50 promotes melanoma angiogenesis by upregulating interleukin-6 expression.

  We found that NF-kappaB p50 expression strongly induced interleukin-6 (IL-6) upregulation in melanoma cells at both the transcriptional and translational levels and that IL-6 production by melanoma cells enhanced the growth of endothelial cells in vitro.

• 12208865(ATF2): An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis.

  Altering the balance of Jun/ATF2 transcriptional activities sensitized melanoma cells to apoptosis , an effect that could be attenuated by inhibiting c-Jun.