IL-1 beta→Interleukin-8→NF-kappa B→ATF2

• 19555923(IL-1+beta): Salivary levels of IL-1beta, IL-6, IL-8, and TNF-alpha in patients with burning mouth syndrome.

  RESULTS : No significant differences were found in the salivary levels of IL-1beta , IL-6 , IL-8 , and TNF-alpha in BMS patients compared with controls.

• 12034025(Interleukin-8): Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation.

  In the present study , we demonstrate that upregulation of interleukin-1beta (IL-1beta) - mediated and tumor necrosis factor-alpha (TNF-alpha) - mediated IL-8 expression in human malignant melanoma cells is modulated by the activation of nuclear factor-kappaB (NF-kappaB).

• 15728492(NF-kappa B): Involvement of TNF and NF-kappa B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages.

  In this region a NF-kappaB site has been described and mutation of this site impairs the induction of the full COX-2 promoter by IFN-gamma.

• 16724115(ATF2): Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development.

  In vivo , the same factors bind to the unmethylated IFN-gamma promoter in T helper type 1 (TH1) cells but not the methylated IFN-gamma promoter in TH2 cells.