IFN-gamma→Interferon-gamma→Interferon-gamma→Cytokines→ATF2

• 19634712(IFN-gamma): Evaluation of whole blood IFNgamma test using PPD and recombinant antigen challenge for diagnosis of pulmonary and extra-pulmonary tuberculosis.

  This study compares recombinant antigens based QFT-G and low cost PPD based interferon test for the diagnosis of PTB and EPTB.

• 18284831(Interferon-gamma): Accuracy of an interferon-gamma release assay to detect active pulmonary and extra-pulmonary tuberculosis.

  CONCLUSION : Although the specificity of the QFT-G to detect active TB was high and its sensitivity low , it was as accurate for the detection of active EPTB as for PTB when the 0.35 IU/ml INF-gamma cut-off concentration was used.

• 17401714(Interferon-gamma): Sensitivity of a whole-blood interferon-gamma assay among patients with pulmonary tuberculosis and variations in T-cell responses during anti-tuberculosis treatment.

  However , it is unclear if IFN-gamma assays can be used to monitor response to TB treatment.

• 17145950(Cytokines): Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment.

  Although there was interindividual variability in the observed responses , the overall results revealed that M. tuberculosis-induced TNF-alpha and IFN-gamma levels showed opposite trends.

• 11342638(ATF2): RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

  IFN-gamma can synergize with TNF-alpha to activate NF-kappaB in a number of cell lines.