IL-1 beta→STAT1 protein, human→STAT1 protein, human→STAT2

• 19643686(IL-1+beta): IL-1beta-511 and IL-1RN*2 polymorphisms in inflammatory bowel disease: An Italian population study and meta-analysis of European studies.

  Crohn 's disease patients with the IL-1beta-511 mutation had a higher rate of complicated disease.

• 12171960(STAT1 protein, human): Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease.

  High levels of suppressor of cytokine signalling (SOCS) -3 expression , an inhibitor of STAT activation , were observed in Crohn 's disease patients and normal controls in western blot experiments whereas no differences were observed for SOCS-1 expression.

• 18591661(STAT1 protein, human): Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations.

  However , despite the crucial role of STAT tyrosine phosphorylation in cytokine signaling , it has not been determined how this modification affects the stability and the conformational flexibility of STAT dimers.

• 19781967(STAT2): Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3.

  The phosphorylation and subsequent activation of Stat3 , a member of the STAT family , has been found to be elevated in a large number of diverse human cancers.