IFN-gamma→Interleukin-6→Interleukin-8→NF-KB

• 19739012(IFN-gamma): Urinary evaluation of the balance between the soluble interferon-gamma receptor (IFN-gammaR1) and the interleukin-4 receptor (IL-4Ralpha) in children with vesicoureteral reflux.

  We planned to investigate the urinary soluble cytokine receptor profile in patients with vesico-ureteric reflux (VUR).

• 8558701(Interleukin-6): Elevated interleukin-8 levels in the urine of children with renal scarring and/or vesicoureteral reflux.

  There were statistically significant differences between urinary interleukin-8 levels in children with and without renal scarring (p = 0.001) , and with and without vesicoureteral reflux (p = 0.0246).

• 11835523(Interleukin-8): Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy.

  We examined the correlation among the levels of urinary monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) , hyperglycemia , and renal injuries in patients with type 2 diabetic nephropathy.

• 20434448(NF-KB): Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells.

  In this study , LPA activated ROCK , p38 , JNK and NF-kappaB pathways and induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) mRNA and protein expression in human endothelial cells.