IL-1 beta→Interleukin 1 Receptor Antagonist Protein→Cytokines→c-fos

• 19747989(IL-1+beta): Alterations in serum levels of inflammatory cytokines (TNF, IL-1alpha, IL-1beta and IL-1Ra) 20 years after sulfur mustard exposure: Sardasht-Iran cohort study.

  Pro-inflammatory cytokines including TNF , IL-1alpha , IL-1beta and IL-1Ra cause systemic inflammatory reactions and numerous changes including altered cell signaling and migration , changes in cytokine production and fever.

• 18675261(Interleukin 1 Receptor Antagonist Protein): Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection.

  Elevation of extracellular glutamate contributes to cell death and functional impairments generated by spinal cord injury (SCI) , in part through the activation of the neurotoxic cytokine interleukin-1beta (IL-1beta).

• 17111361(Cytokines): Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved.

  At 30-45 minutes post SCI , IL-1beta and TNF-positive cells could already be seen over the entire spinal cord segment analyzed.

• 20111900(c-fos): Increase of c-Fos and c-Jun expression in spinal and cranial motoneurons of the degenerating muscle mouse (Scn8a(dmu)).

  The mutation also increased the number of c-Jun-immunoreactive motoneurons in the cervical spinal cord (wild type , 1.6 + / - 0.8 ; dmu , 12.1 + / - 2.1) , Vm (wild type , 41.4 + / - 18.0 ; dmu , 123.1 + / - 11.7) , and X (wild type , 39.1 + / - 10.7 ; dmu , 92.8 + / - 17.8).