IFN-gamma→Interferon-gamma→Tryptophan→Tryptophan→STAT2

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4 +896 A/G allele G were more likely to need tympanostomy than noncarriers.

• 19919944(Interferon-gamma): Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus.

  CONCLUSION : Several SNP in IFNG are associated with SLE susceptibility , and the risk allele of an associated SNP (rs2430561) located in an NF-kappaB binding site has elevated IFNG expression versus the non-risk allele , supporting that elevated IFNG expression is associated with increased SLE susceptibility.

• 10834318(Tryptophan): Enhanced tryptophan degradation in systemic lupus erythematosus.

  The significant correlation found between K/T and neopterin (rs = 0.808 , p (0.001) , a marker of immune activation , points to a role of immune activation to be responsible for tryptophan degradation in SLE patients.

• 3095441(Tryptophan): Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity.

  Human recombinant gamma interferon (rHuIFN-gamma) was found to induce tryptophan degradation in vitro in human cell cultures and in vivo in participants in phase I clinical trials.

• 11932384(STAT2): Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction.

  The components of the IFN signaling system that are required for STAT protein degradation by these paramyxoviruses have been investigated in a series of human somatic cell lines deficient in IFN signaling proteins.