IFN-gamma→Interleukin-6→STAT2

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed.

• 18948841(Interleukin-6): Lipopolysaccharide induces IL-6 production in respiratory syncytial virus-infected airway epithelial cells through the toll-like receptor 4 signaling pathway.

  RSV was shown to alter TLR4 membrane and cytosolic location in epithelial cells.

• 14722224(STAT2): Specific inhibition of type I interferon signal transduction by respiratory syncytial virus.

  Initial experiments demonstrated inhibition of antiviral gene expression induced by IFN-alpha and IFN-beta , but not IFN-gamma , in epithelial cells infected with RSV.