IFN-gamma→Interferon-gamma→Cytokines→ATF3

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed.

• 19919944(Interferon-gamma): Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus.

  This study examined the association of IFNG polymorphisms with SLE susceptibility.

• 14654712(Cytokines): Relationship of p53 with other oncogenes, cytokines and systemic lupus erythematosus activity.

  RESULTS : SLE patients had higher levels of p53 protein (0.16 + / - 0.33 ng/dl) than controls (0.014 + / - 0.02 ng/dl ; p = 0.006).

• 15933712(ATF3): Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.

  ATF3 , but not the Delta102-139 protein , binds the p53 carboxy-terminus and diminishes its ubiquitination and nuclear export.