IFN-gamma→Interleukin-10→Insulin-Like Growth Factor I→ATF3

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4 +896 A/G allele G were more likely to need tympanostomy than noncarriers.

• 11821159(Interleukin-10): Polymorphisms of interferon-gamma gene CA-repeat and interleukin-10 promoter region (-592A/C) in Japanese type I diabetes.

  No significant differences of global IFNG allele frequencies were found between controls and type I diabetic patients , and between each subgroup of the patients and controls.

• 12387452(Insulin-Like Growth Factor I): Early gene responses of trophic factors in nerve regeneration differ in experimental type 1 and type 2 diabetic polyneuropathies.

  These differences may account for the more efficient nerve regeneration seen in type 2 diabetic polyneuropathy.

• 18521006(ATF3): Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats.

  Diabetes (BB ; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.