IFN-gamma→Chemokines→JunD

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed.

• 18755634(Chemokines): TLR4 single-nucleotide polymorphisms alter mucosal cytokine and chemokine patterns in Mexican patients with Helicobacter pylori-associated gastroduodenal diseases.

  These results suggest that TLR4 SNPs contributes importantly to the clinical outcome of H. pylori infection.

• 18625013(JunD): Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells.

  Different clinical isolates of H. pylori showed various abilities to induce AP-1 DNA binding.