IFN-gamma→Interferon-gamma→Interleukin-1beta→c-fos

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4 +896 A/G allele G were more likely to need tympanostomy than noncarriers.

• 14681912(Interferon-gamma): Dinucleotide repeat polymorphism in interferon-gamma gene is not associated with sporadic Alzheimer's disease.

  There were no significant differences in allele frequency between the AD and control groups.

• 18449948(Interleukin-1beta): Transcription factor Sp1 dysregulation in Alzheimer's disease.

  These results indicate that elements of regulatory pathways involving transcription factor Sp1 may be useful targets for therapeutic intervention to prevent or reverse AD.

• 19595408(c-fos): Propensity for HBZ-SP1 isoform of HTLV-I to inhibit c-Jun activity correlates with sequestration of c-Jun into nuclear bodies rather than inhibition of its DNA-binding activity.

  This interaction leads to a reduction of c-Jun DNA-binding activity and prevents the protein from activating transcription of AP-1-dependent promoters.