IFN-gamma→Interferon-gamma→Interleukin-10→STAT1

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4 +896 A/G allele G were more likely to need tympanostomy than noncarriers.

• 19919944(Interferon-gamma): Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus.

  Elevated expression of IFNG has been associated with systemic lupus erythematosus (SLE).

• 19962219(Interleukin-10): [Regulatory T cells and systemic autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis, primary Sjogren's syndrome]

  In this article , past and recent studies of Tregs in human systemic lupus erythematosus (SLE) , rheumatoid arthritis (RA) and primary Sjogren 's syndrome (pGSS) are reviewed.

• 19889125(STAT1): IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells.

  Importantly , STAT1-deficient Tregs failed to control allograft rejection in vivo.