IFN-gamma→Interferon-gamma→Tumor Necrosis Factor-alpha→STAT1

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4 +896 A/G allele G were more likely to need tympanostomy than noncarriers.

• 17713715(Interferon-gamma): Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE.

  The allele frequencies of the IFNG (+874) gene polymorphism were not significantly different between SLE patients and control subjects (72.7 vs 77 %).

• 9326391(Tumor Necrosis Factor-alpha): A TNF-alpha promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis.

  Our findings suggest that this promoter polymorphism itself or a gene in linkage disequilibrium with tumor necrosis factor-alpha predispose to the development of psoriasis.

• 19924133(STAT1): Possible roles of IL-27 in the pathogenesis of psoriasis.

  However , its importance in psoriasis is unknown.