IFN-gamma→Interleukin-6→Integrins→c-jun

• 19773677(IFN-gamma): Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis.

  Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed.

• 18948841(Interleukin-6): Lipopolysaccharide induces IL-6 production in respiratory syncytial virus-infected airway epithelial cells through the toll-like receptor 4 signaling pathway.

  RSV was shown to alter TLR4 membrane and cytosolic location in epithelial cells.

• 8666675(Integrins): Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

  The integrin alpha v beta 6 is only expressed in epithelial cells.

• 19960514(c-jun): Increased integrin alpha5beta1 heterodimer formation and reduced c-Jun expression are involved in integrin beta1 overexpression-mediated cell growth arrest.

  Solely overexpressed beta (1) subunit could induce the expression of diverse alpha subunit in different cell lines , among which alpha (5) subunit was found to be correlated with integrin beta (1) - mediated growth arrest.