IL-1 beta→Dexamethasone→CREB

• 19822562(IL-1+beta): Increased umbilical cord plasma interleukin-1 beta levels was correlated with adverse outcomes of neonatal hypoxic-ischemic encephalopathy.

  Thus , umbilical concentrations of IL-1 beta were associated with the grades and adverse outcomes of HIE.

• 9042522(Dexamethasone): Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism.

  However , dexamethasone did inhibit the induction of c-fos transcription seen following HIE , and subsequent evidence of apoptosis.

• 9037515(CREB): The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair.

  The cyclic AMP-responsive element binding protein (CREB) is a basally expressed , post-translationally activated transcription factor that has been implicated in the trans-activation of a number of genes in response to cAMP and calcium signals.