IL-8→NF-kappa B→NF-kappa B→ATF2

• 19887538(IL-8): Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus.

  METHODS : This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and 108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection.

• 10196356(NF-kappa B): Incomplete regulation of NF-kappaB by IkappaBalpha during respiratory syncytial virus infection in A549 cells.

  However , during RSV infection , IkappaBalpha has only a partial inhibitory effect on NF-kappaB activation.

• 9865694(NF-kappa B): The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.

  The 2.3 A crystal structure of IkappaBalpha in complex with the NF-kappaB p50/p65 heterodimer reveals mechanisms of these inhibitory activities.

• 10871852(ATF2): p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression.

  ASK1/p38 silences the Fas promoter by inhibition of IkappaBalpha phosphorylation - thereby limiting NF-kappaB activity.