IL-8→Interleukin-8→Transcription Factor AP-1→JunD

• 19887538(IL-8): Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus.

  METHODS : This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and 108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection.

• 10820277(Interleukin-8): Requirement of a novel upstream response element in respiratory syncytial virus-induced IL-8 gene expression.

  Instead , RSV requires participation of a previously unrecognized element , spanning from -162 to -132 nt , that we term the RSV response element (RSVRE) , and a previously characterized element at -132 to -99 nt , containing an AP-1 binding site.

• 9593012(Transcription Factor AP-1): Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-kappaB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium.

  Mutation of the NF-IL6 nt size=3 color="#000000">sitent> had minimal effect in the presence of intact binding nt size=3 color="#000000">sitent>s for nt size=3 color="#000000">NF-kappaBnt> and AP-1.

• 11526502(JunD): Functional cooperation between JunD and NF-kappaB in rat hepatocytes.

  AP-1 and NF-kappaB are rapidly activated during liver regeneration.