IL-8→Interleukin-8→Interferon-gamma→STAT1

• 19887538(IL-8): Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus.

  RESULTS : (i) The frequency of IL-8 -251 T in cases was dramatically high (OR = 2.08 , p = 0.0002).

• 7519169(Interleukin-8): Interleukin-8, interleukin-6, and soluble tumour necrosis factor receptor type I release from a human pulmonary epithelial cell line (A549) exposed to respiratory syncytial virus.

  In addition , IL-3 , G-CSF , IFN-gamma and TGF-beta 2 , albeit at high concentrations , induced a low IL-8 release from non-infected A549 cells.

• 17310225(Interferon-gamma): Pulmonary epithelial cells are a source of interferon-gamma in response to Mycobacterium tuberculosis infection.

  Secretion profile indicated that M. tuberculosis-infected A549 released significantly high concentration of IFN-gamma at 48 and 72 h post-infection.

• 19929594(STAT1): Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma.

  Together , IL-1beta and IFN-gamma induce ip-10 synergistically.