IL-8→Interleukin-1→NF-kappa B→CREB

• 19887538(IL-8): Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus.

  OBJECTIVE : To study the association of haplotypes of IL-8 -251 T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV).

• 9191851(Interleukin-1): Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-kappa B and is inhibited by sodium salicylate and aspirin.

  Infection of the lung epithelial cell line A549 by respiratory syncytial virus (RSV) resulted in the elevated synthesis of multiple cellular cytokines , including a number of interleukins (ILs).

• 11922866(NF-kappa B): Respiratory syncytial virus and TNF alpha induction of chemokine gene expression involves differential activation of Rel A and NF-kappa B1.

  Both TNFalpha and RSV strongly induced Rel A the activation subunit of NF-kappaB , whereas only TNFalpha was able to substantially induce the p50 subunit.

• 20103840(CREB): Bilirubin effect on endothelial adhesion molecules expression is mediated by the NF-kappaB signaling pathway.

  UCB prevented the nuclear translocation of NF-kappaB induced by TNFalpha.