IFN-gamma→Interleukin-6→Interferons→STAT2

• 19958302(IFN-gamma): Cytokine gene polymorphisms and sudden infant death syndrome.

  CONCLUSION : This study indicates that specific interleukin genotypes are a part of a genetic make up that make infants sleeping prone at risk for SIDS.

• 8392861(Interleukin-6): Cytokine release from human peripheral blood leucocytes incubated with endotoxin with and without prior infection with influenza virus: relevance to the sudden infant death syndrome.

  To determine whether cytokines may be involved in this inflammatory response , levels of interleukin (IL) -1 beta , IL-6 and tumor necrosis factor (TNF) - alpha were examined , using ELISA assays , in culture supernatants of human peripheral blood leucocytes infected with influenza virus and subsequently incubated with endotoxin.

• 9301532(Interferons): Regulation of HLA class I and II expression by interferons and influenza A virus in human peripheral blood mononuclear cells.

  Influenza A virus infection of macrophages resulted in temporary increases in HLA class I , beta 2-microglobulin and class II antigen expression.

• 11952149(STAT2): Interferon type I downregulates human parainfluenza virus type 3-induced major histocompatibility complex class II expression.

  The inhibition by IFN-alpha/beta of MHC class II expression may play a regulatory role in virus induced autoimmune disease mediated by MHC class II aberrant expression.