IFN-gamma→Tumor Necrosis Factor-alpha→Lymphocyte Function-Associated Antigen-1→c-fos

• 20020653(IFN-gamma): [Influence of immunological parameters on the effectiveness of systemic and loco-regional immunotherapy in disseminated renal carcinoma]

  Multivariate evaluation pointed to prognostic value of IL-6 (spontaneous and induced production) , IL-8 (spontaneous and induced production) , TNF-alpha (spontaneous production) , IFN-gamma (induced production) , TNK-cells (CD3 + CD16 + CD56 +) , and T-regulatory cells (CD4 + CD25 + Treg).

• 10365136(Tumor Necrosis Factor-alpha): The differential expression of proinflammatory cytokines IL-6, IL-8 and TNF-alpha in renal cell carcinoma.

  Our results clearly demonstrate that among the various cytokines analyzed a predominant release of TNF-alpha , IL-8 and IL-6 is obtained.

• 10605013(Lymphocyte Function-Associated Antigen-1): Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers.

  Although the on-rate kinetics of cytokine production were nearly identical , activated T cells produced more IFN-gamma , but less TNF-alpha , than memory T cells.

• 20018662(c-fos): Delayed wave of c-Fos expression in the dorsal hippocampus involved specifically in persistence of long-term memory storage.

  Although persistence is a key characteristic of memory storage , its mechanisms are scarcely characterized.