IFN-gamma→Interleukin-8→Interleukin-8→BRCA1

• 20020653(IFN-gamma): [Influence of immunological parameters on the effectiveness of systemic and loco-regional immunotherapy in disseminated renal carcinoma]

  Multivariate evaluation pointed to prognostic value of IL-6 (spontaneous and induced production) , IL-8 (spontaneous and induced production) , TNF-alpha (spontaneous production) , IFN-gamma (induced production) , TNK-cells (CD3 + CD16 + CD56 +) , and T-regulatory cells (CD4 + CD25 + Treg).

• 1739130(Interleukin-8): Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas.

  All cell lines expressed high levels of IL-8 mRNA on stimulation with either IL-1 beta or TNF-alpha , but not lipopolysaccharide ; one expressed the gene constitutively.

• 17621625(Interleukin-8): Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells.

  We aimed to study the role (s) of IL-8 in ER-negative breast cancer progression by using RNA interference to specifically knockdown IL-8 expression in ER-negative breast cancer cell lines MDA-MB-231 and MDA-MB-468.

• 20346095(BRCA1): Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

  There is a strong association between BRCA1 mutation carrier status and estrogen receptor-negative breast cancer.