IL-1 beta→Tumor Necrosis Factor-alpha→JunD

• 20060205(IL-1+beta): The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women.

  STUDY DESIGN : The aim of the present study was to examine associations between cytokine gene polymorphisms (IL-1beta , IL-2 , IL-6) and bone mineral density (BMD) values in postmenopausal women.

• 15354858(Tumor Necrosis Factor-alpha): Bone mineral density of the lumbar spine is associated with TNF gene polymorphisms in early postmenopausal Japanese women.

  We investigated the relationships between tumor necrosis factor (TNF) gene polymorphism , circulating TNF-alpha (TNF-alpha) concentrations , and bone mineral density (BMD) in the lumbar spine.

• 14617571(JunD): Tumor necrosis factor alpha (TNF) increases granulosa cell proliferation: dependence on c-Jun and TNF receptor type 1.

  Antisense oligonucleotides for c-Jun blocked cell proliferation induced by TNF.