IL-1 beta→Interleukin-1→Interleukin-1→STAT2

• 20085044(IL-1+beta): Effect of peritoneal lavage on TNF-alpha, IL-1beta, and IL-6 levels and mortality in intraabdominal infections.

  The aim of this study is to investigate the effect of peritoneal lavage on TNF-alpha , IL-1beta , and IL-6 levels and mortality when the source control has or has not been established.

• 16616208(Interleukin-1): The effect of IL-1beta on the expression of inflammatory cytokines and their receptors in human chondrocytes.

  The expression of IL-1beta , IL-8 , and TNF-alpha markedly increased in the presence of IL-1beta after day 14 of culture.

• 17032168(Interleukin-1): A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression.

  Because the induction of interleukin-1beta (IL-1beta) is critical to antibacterial host defenses and its excessive generation is a prominent component of sepsis , regulation of this proinflammatory cytokine is a critical factor in the immune response to lipopolysaccharide (LPS).

• 16940534(STAT2): Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.

  Emerging data have indicated that hepatitis C virus (HCV) subverts the host antiviral response to ensure its persistence.