IL-1 beta→Interleukin-1→STAT1

• 20085044(IL-1+beta): Effect of peritoneal lavage on TNF-alpha, IL-1beta, and IL-6 levels and mortality in intraabdominal infections.

  The aim of this study is to investigate the effect of peritoneal lavage on TNF-alpha , IL-1beta , and IL-6 levels and mortality when the source control has or has not been established.

• 16616208(Interleukin-1): The effect of IL-1beta on the expression of inflammatory cytokines and their receptors in human chondrocytes.

  The expression of IL-1beta , IL-8 , and TNF-alpha markedly increased in the presence of IL-1beta after day 14 of culture.

• 17032168(STAT1): A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression.

  These studies support the hypothesis that the expression of IL-1beta requires both the MyD88-dependent induction of IL-1beta mRNA and pro-IL-1beta as well as the MyD88-independent , Stat1-mediated processing of that gene product into active cytokine.