IFN-gamma→Interleukin-8→Transcription Factor AP-1→JunD

• 20090849(IFN-gamma): Clinical findings and pro-inflammatory cytokines in dengue patients in Western India: a facility-based study.

  High levels of IL-6 and IL-8 were shown to associate with DHF.

• 11991987(Interleukin-8): Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge.

  Nuclear factor kappa B (NF-kappa B) and nuclear factor IL-6 (NFIL-6) are primary mediators of IL-8 expression.

• 11399048(Transcription Factor AP-1): Nitric oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation.

  Mutation of either the AP-1 site or the NF-IL-6 site on the IL-8 promoter suppressed the TNF-alpha-induced activation , suggesting cooperation between these transcription factors and transcription factor NF-kappaB.

• 1429597(JunD): Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun.

  The proteins Fos and Jun dimerize to constitute the transcription factor AP-1 which is known to respond to treatment with phorbol esters.