IL-1 beta→Tumor Necrosis Factor-alpha→Interferon-alpha→Histocompatibility Antigens→STAT2

• 20104073(IL-1+beta): Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients.

  OBJECTIVE : To assess the serum levels of interleukin 1beta (IL-1beta) in elderly depressed patients in comparison with nondepressed healthy elderly subjects.

• 9180195(Tumor Necrosis Factor-alpha): Decreased short-term production of tumor necrosis factor-alpha and interleukin-1beta in human immunodeficiency virus-seropositive subjects.

  Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were measured by ELISA in 4.5-h , lipopolysaccharide-stimulated whole blood cultures of 347 human immunodeficiency virus type 1-infected patients and 107 healthy seronegative controls.

• 8697147(Interferon-alpha): Stimulation of macrophage synthesis of complement C1q by interferon-gamma mediated by endogenous interferon-alpha/beta.

  IFN-gamma was confirmed by ELISA to stimulate a six - to eightfold increase in macrophage secretion of IFN-alpha/beta compared with untreated control cells.

• 3129509(Histocompatibility Antigens): Recombinant human IFN-gamma, but not IFN-alpha or IFN-beta, enhances MHC- and non-MHC-encoded glycoproteins by a protein synthesis-dependent mechanism.

  In contrast , IFN-gamma does require de novo protein synthesis for its modulatory activity.

• 12804771(STAT2): Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.

  We found that expression of V protein inhibited interferon (IFN) - alpha/beta signaling but not IFN-gamma signaling.