TNF-alpha→HLA Antigens→Interferon-alpha→STAT2

• 20104750(TNF-alpha): [The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and nonalcoholic fatty liver]

  OBJECTIVE : To study the roles of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver.

• 2501137(HLA Antigens): Interferon alpha and gamma positive mononuclear cells and HLA antigen expression on hepatocyte membrane in the liver in chronic type B and non-A, non-B hepatitis.

  Among type B chronic liver disease , the percentages of both interferon alpha - and gamma-positive mononuclear cells were highest in patients with chronic active hepatitis , and their levels were higher in patients who had serum HBe antigen , indicating that local expression of interferon closely correlates with activity of disease and virus replication.

• 1841421(Interferon-alpha): [The interferon system in chronic brucellosis]

  The purpose of the paper was to evaluate activity of interferon system in a group of patients with chronic brucellosis.

• 18774582(STAT2): Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon.

  We have characterized mouse genomic clones containing the promoter regions required for Adar1 gene transcription and analyzed interferon induction of the p150 protein using mutant mouse cell lines.