TNF-alpha→Tumor Necrosis Factor-alpha→Plasminogen Activator Inhibitor 1→STAT1

• 20104750(TNF-alpha): [The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and nonalcoholic fatty liver]

  METHODS : The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver was detected by ELISA after culturing for 72 hours in vitro , as well as patients with chronic hepatitis C and the normal control.

• 10515837(Tumor Necrosis Factor-alpha): Intrahepatic expression of interleukin-1beta and tumor necrosis factor-alpha in chronic hepatitis C.

  The intrahepatic expression of interleukin (IL) -1 beta and tumor necrosis factor (TNF) - alpha was studied in liver specimens from patients with chronic hepatitis C (n = 29) and primary biliary cirrhosis (PBC ; n = 12) and from normal controls (n = 19).

• 10516146(Plasminogen Activator Inhibitor 1): IL-1beta mediates induction of hepatic type 1 plasminogen activator inhibitor in response to local tissue injury.

  We studied the acute phase regulation of murine hepatic PAI-1 in response to systemic toxicity and local tissue injury in both wild-type mice and in mice in which the interleukin (IL) -1 beta gene had been inactivated by gene targeting.

• 19701245(STAT1): Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3.

  Tumor cells induced the release of interleukin (IL) -1 beta from macrophages , which induced phosphorylation of GSK3beta , stabilized beta-catenin , enhanced T-cell factor (TCF) - dependent gene activation and induced the expression of Wnt target genes in tumor cells.