TNF-alpha→NF-kappa B→NF-kappa B→Tumor Necrosis Factor-alpha→JunD

• 20108015(TNF-alpha): Inclusion body myositis in a patient with long standing rheumatoid arthritis treated with anti-TNFalpha and rituximab.

  Further workup including muscle biopsy revealed IBM.

• 9779924(NF-kappa B): Immunolocalization of transcription factor NF-kappaB in inclusion-body myositis muscle and at normal human neuromuscular junctions.

  Our data suggest that NF-kappaB plays a role in IBM pathogenesis.

• 2691328(NF-kappa B): A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

  Surprisingly , NF-kappaB could only be inactivated by I kappaB when p65 was bound.

• 19706766(Tumor Necrosis Factor-alpha): MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.

  We also show that an inhibitor of MUC1-C oligomerization blocks the interaction with NF-kappaB p65 in vitro and in cells.

• 11526502(JunD): Functional cooperation between JunD and NF-kappaB in rat hepatocytes.

  AP-1 and NF-kappaB are rapidly activated during liver regeneration.