TNF-alpha→resveratrol→BRCA1

• 20118277(TNF-alpha): Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.

  Antioxidant inhibited both the phenotypic and functional changes of DCs , underlining the importance of oxidative stress in these processes.

• 17220179(resveratrol): Resveratrol increases vascular oxidative stress resistance.

  Thus resveratrol seems to increase vascular oxidative stress resistance by scavenging H (2) O (2) and preventing oxidative stress-induced endothelial cell death.

• 19073505(BRCA1): A BRCA1 mutation is not associated with increased indicators of oxidative stress.

  Future studies are warranted to evaluate whether strategies aimed at minimizing oxidative stress might aid in the prevention of hereditary breast cancer.