TNF-alpha→Tumor Necrosis Factor-alpha→Interleukin-5→STAT2

• 20132806(TNF-alpha): Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population.

  RESULTS : SNPs IL6 -174 G/C and TNFalpha -308 G/A are associated neither with T2D (p = 0.89 , p = 0.34 respectively) nor with risk for overweight (p = 0.86 , p = 0.12 respectively) in Tunisian population.

• 12719394(Tumor Necrosis Factor-alpha): Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections.

  Significant correlations were observed between IL6 and TNFalpha or IL10 as well as IL10 and IFNgamma in infected infants.

• 17492594(Interleukin-5): Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection.

  BACKGROUND : Respiratory syncytial virus (RSV) infection is the most common respiratory viral infection resulting in hospitalizations in infants worldwide.

• 15994826(STAT2): Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness.

  Respiratory syncytial virus (RSV) subverts the antiviral interferon (IFN) response , but the mechanism for this evasion was unclear.