IL-1 beta→lycopene→Receptors, TNF-Related Apoptosis-Inducing Ligand→ATF3

• 20151805(IL-1+beta): Initial periodontal therapy reduced systemic and local 25-hydroxy vitamin D(3) and interleukin-1beta in patients with aggressive periodontitis.

  CONCLUSIONS : 25-hydroxy vitamin D (3) and interleukin-1beta levels were systemically and locally reduced in patients with GAgP by initial periodontal therapy.

• 15084515(lycopene): Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model.

  Epidemiological studies have consistently associated high intakes of lycopene or vitamin E with a reduced prostate cancer risk.

• 15172122(Receptors, TNF-Related Apoptosis-Inducing Ligand): eNOS protects prostate cancer cells from TRAIL-induced apoptosis.

  Taken together , these results indicate that eNOS can regulate the sensitivity of prostate cancer cells to TRAIL , and down-regulation of eNOS activity may sensitize prostate cancer cells to TRAIL-based therapy.

• 18755691(ATF3): KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.

  Thus , ATF3 is a key mediator of KLF6-induced apoptosis in prostate cancer cells.