IL-1 beta→Interferon-gamma→p38 Mitogen-Activated Protein Kinases→ATF2

• 20157206(IL-1+beta): [Correlative analysis between indices of rheological particularities of blood, IL-1beta and lipid profile in patients with chronic cor pulmonary]

  Working-out the algorithm of the diagnosis of cor pulmonary on the grounds of mathematical modeling and analysis of laboratory indices.

• 14680077(Interferon-gamma): Does interferon-gamma improve pulmonary function in idiopathic pulmonary fibrosis?

  Idiopathic pulmonary fibrosis (IPF) is a disease with progressive and devastating deterioration of lung function and a fatal prognosis , despite aggressive therapeutic attempts , which , in the majority of cases are futile.

• 12375272(p38 Mitogen-Activated Protein Kinases): MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis.

  This study investigated whether MAPKs are activated and associated with lung injury in lung tissues from patients with idiopathic pulmonary fibrosis (IPF).

• 10640438(ATF2): Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes.

  The transcription factors , c-Jun and ATF2 , are phosphorylated by the MAPKs and are implicated in the upregulation of c-Jun.