IL-8→Interleukin-10→Interleukin-6→ATF2

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  In a cross-sectional study , the geometric mean of IL-8 level was significantly higher in the patients with A-T (P (.0001).

• 18479302(Interleukin-10): Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma.

  Consequently , patients with elevated IL-6 , IL-8 and IL-10 levels prior to treatment had a lower response to therapy.

• 8895217(Interleukin-6): Effects of exogenous IL-1 beta, TNF alpha, IL-6, IL-8 and LIF on cytokine production by human articular chondrocytes.

  Finally , LIF stimulated IL-1 beta , IL-6 and IL-8 productions.

• 10640438(ATF2): Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes.

  However , IL-1 beta induced a greater increase in c-Jun protein.