IL-8→Interleukin-8→Interleukin-8→ATF2

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 7640519(Interleukin-8): Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load.

  We studied the constitutive production of IL-8 by melanoma cell lines and the serum concentrations in patients with metastatic melanoma.

• 10976534(Interleukin-8): Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity.

  The purpose of this study was to determine whether constitutive NF-kappaB activity regulates the expression level of interleukin-8 (IL-8) in metastatic human melanoma cells.

• 11342638(ATF2): RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

  IFN-gamma can synergize with TNF-alpha to activate NF-kappaB in a number of cell lines.